By D. Kabelitz, T. Pohl, K. Pechhold (auth.), Guido Kroemer, Carlos Martinez-A. (eds.)
In any circulate in their existence, immune cells, specially T and B lymphocytes, are faced with an important selection: to proceed their life or to dedicate a kind of metabolic suicide that's known as apoptosis or programmed mobile dying. not like such a lot philosophers, lymphocytes and their precursors are continuously prone to suicide, and it even appears to be like that the standard reason behind T or B cellphone removal is suicide instead of dying from ordinary reasons, injuries or homicide. This e-book presents an unlimited review of lymphocytes suicide: exterior triggers and inner explanations resulting in suicidal impulses, accomplices in self-destruction, guns implicated in self-execution, elimination of lifeless our bodies and pharmacological prevention of suicide. lots of the chapters during this booklet are dedicated to the body structure of apoptosis. The target is to unmask the exterior triggers of apoptosis, resolve the sign transduction seasoned cesses concerned therein and describe the position of oncogenes, "death genes" and effector molecules within the apoptotic cas cade. the rest chapters take care of the pathophysiologi cal features of lymphocyte apoptosis, particularly, as a number contribution to HIV-induced lymphopenia, and healing options for the avoidance of lymphocyte demise. we're convinced that this compendium will give a contribution to the exploration of mobile suicide, not just from a simple scientist's standpoint but additionally in regards to the potential medical implications of apoptosis (dys)regulation. faraway from having a dark influence at the reader, mobile suicide could therefore supply a resource of either highbrow pleasure and healing inspiration.
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Additional info for Apoptosis in Immunology
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48 1 Introduction The immune system is endowed with a multitude of different mechanisms to eliminate, paralyze or neutralize T and B lymphocytes expressing self-reactive antigen receptors that might endanger the individual's life. The ability of both types of lymphocytes to recognize and react to different stimuli is a learning process that occurs during lymphocyte differentiation, and the mechanisms implicated in self-tolerance intervene at determined control points following developmental criteria.
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Apoptosis in Immunology by D. Kabelitz, T. Pohl, K. Pechhold (auth.), Guido Kroemer, Carlos Martinez-A. (eds.)