Apoptosis in Immunology - download pdf or read online

By D. Kabelitz, T. Pohl, K. Pechhold (auth.), Guido Kroemer, Carlos Martinez-A. (eds.)

ISBN-10: 3642794378

ISBN-13: 9783642794377

ISBN-10: 3642794394

ISBN-13: 9783642794391

In any circulate in their existence, immune cells, specially T and B lymphocytes, are faced with an important selection: to proceed their life or to dedicate a kind of metabolic suicide that's known as apoptosis or programmed mobile dying. not like such a lot philosophers, lymphocytes and their precursors are continuously prone to suicide, and it even appears to be like that the standard reason behind T or B cellphone removal is suicide instead of dying from ordinary reasons, injuries or homicide. This e-book presents an unlimited review of lymphocytes suicide: exterior triggers and inner explanations resulting in suicidal impulses, accomplices in self-destruction, guns implicated in self-execution, elimination of lifeless our bodies and pharmacological prevention of suicide. lots of the chapters during this booklet are dedicated to the body structure of apoptosis. The target is to unmask the exterior triggers of apoptosis, resolve the sign transduction seasoned­ cesses concerned therein and describe the position of oncogenes, "death genes" and effector molecules within the apoptotic cas­ cade. the rest chapters take care of the pathophysiologi­ cal features of lymphocyte apoptosis, particularly, as a number contribution to HIV-induced lymphopenia, and healing options for the avoidance of lymphocyte demise. we're convinced that this compendium will give a contribution to the exploration of mobile suicide, not just from a simple scientist's standpoint but additionally in regards to the potential medical implications of apoptosis (dys)regulation. faraway from having a dark influence at the reader, mobile suicide could therefore supply a resource of either highbrow pleasure and healing inspiration.

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Science 262: 1448-1451 Baixeras E, Kroemer G, Cuende E, Marquez C, Bosca L, Martinez JEA. Martinez AC (1993) Signal transduction pathways involved in B-cell induction. Immunol Rev 132: 5-47 Benhamou LE, Cazenave P-A, Sarthou P (1990) Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells. Eur J Immunol 20: 1405-1407 Benhamou LE, Watanabe T, Kitamura D, Cazenave P-A, Sarthou P (1994) Signaling properties of anti immunoglobulin resistant variants of WEHI-231. Eur J Immunol 24: 1993-1999 Bijsterbosch MK, Klaus GGB (1987) Tumor-promoting phorbol esters suppress receptor-stimulated inositol phospholipid degradation and Ca'+ mobilization in mouse lymphocytes, Eur J Immunol 17: 113-118 Bishop GA, Ramirez LM, Koretzky GA (1993) Growth inhibition of a B-cell clone mediated by ligation of IL-4 receptors or membrane IgM.

48 1 Introduction The immune system is endowed with a multitude of different mechanisms to eliminate, paralyze or neutralize T and B lymphocytes expressing self-reactive antigen receptors that might endanger the individual's life. The ability of both types of lymphocytes to recognize and react to different stimuli is a learning process that occurs during lymphocyte differentiation, and the mechanisms implicated in self-tolerance intervene at determined control points following developmental criteria.

Curr Opin Immunol 6: 279-289 Lederman S, Yellin MJ. Covey LR, Cleary AM, Callard R, Chess L (1993) Nonantigen signals for B-cell growth and differentiation to antibody secretion. Curr Opin Immunol 5: 439-444 Lederman S, Yellin MJ, Cleary AM, Pernis A, Inghirami G, Cohn LE, Covey LR, Lee JJ, Rothman P, Chess L (1994) T-Bam/CD40-L on helper T lymphocytes augments Iymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. J Immunol 152: 2163-2171 34 P.

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Apoptosis in Immunology by D. Kabelitz, T. Pohl, K. Pechhold (auth.), Guido Kroemer, Carlos Martinez-A. (eds.)

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