By Joachim R. Kalden, Martin Herrmann
This is often the 1st accomplished e-book in regards to the courting among apoptosis and autoimmune illnesses. It bargains a different updated evaluation on learn effects at the faulty execution of apoptosis and the unfinished clearance of apoptotic cells. The molecular and mobile mechanisms concerned are defined intimately. As a potential end result of apoptotic disorder, the advance of critical autoimmune illnesses (e.g., rheumatoid arthritis, systemic lupus erythematosus) is mentioned. An outlook on destiny learn themes comprises the overview of novel healing thoughts.
Read Online or Download Apoptosis and Autoimmunity: From Mechanisms to Treatments PDF
Best immunology books
Analytical Molecular Biology illustrates the significance of easy analytical tools utilized to a couple uncomplicated molecular biology difficulties, with an emphasis at the value of organic difficulties, instead of the complexity of arithmetic. First, the ebook examines an important experimental information for a particular challenge.
Autoimmune ailments are different and accountable for huge morbidity. Their etiology is still principally unknown, and present treatment with anti inflammatory medicines is vulnerable to antagonistic results, and infrequently healing. New treatments with anti-cytokine antibodies or receptors are promising, yet require common management of pricy protein medications.
Ever because the delivery of molecular biology, the tantalizing probability of treating illness at its genetic roots has turn into more and more possible. Gene treatment although nonetheless in its infancy continues to be one of many preferred components of study in medication. Its strategy makes use of a gene move automobile (''vector'') to convey healing DNA or RNA to cells of the physique so one can rectify the disorder that's inflicting the sickness.
This booklet offers readers an in depth assessment of recent growth in easy and medical examine on melanoma immunotherapy. due to speedy advances in molecular biology and immunology, it has turn into more and more obvious that melanoma development is prompted by means of host immune responses. With the good fortune of a couple of medical trials, immunotherapy has develop into a promising remedy modality of melanoma.
- Immunology for Pharmacy Students
- Molecular mechanisms of conformational diseases
- Analytical Techniques for Clinical Chemistry: Methods and Applications
- Experts in Uncertainty: Opinion and Subjective Probability in Science (Environmental Ethics and Science Policy)
- Applications of Immunocytochemistry
- Immunotherapy in Transplantation: Principles and Practice
Additional resources for Apoptosis and Autoimmunity: From Mechanisms to Treatments
FADD, a novel death domain-containing protein, inter- 29 30 2 Caspase Knockouts: Matters of Life and Death 20 21 22 23 24 25 26 27 28 acts with the death domain of Fas and initiates apoptosis. Cell 1995, 81, 505–12. Boldin, M. , Varfolomeev, E. , Mett, I. , Camonis, J. H. and Wallach, D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem 1995, 270, 7795–8. Medema, J. , Kischkel, F. , Krammer, P. H. and Peter, M. E.
Rakic, P. and Flavell, R A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996, 384, 368–72. , Soengas, M. , Duncan, G. , Kaufman, S. , Lowe, S. W. and Mak, T. W. Essential contribution of caspase-3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 1998, 12, 806–19. , Braun, M. , Denis, F. and Sekaly, R. P. Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J Exp Med 1997, 186, 1503–12.
Bratton, D. L. and Henson, P. M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992, 148, 2207–16. Thornberry, N. , Bull, H. , Calaycay, J. , Chapman, K. , Howard, A. , Kostura, M. , Miller, D. , Molineaux, S. , Weidner, J. , et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 1992, 356, 768–74. Stennicke, H. R. and Salvesen, G. S. Catalytic properties of the caspases.
Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann