Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann PDF

By Joachim R. Kalden, Martin Herrmann

ISBN-10: 0471239577

ISBN-13: 9780471239574

ISBN-10: 0471348899

ISBN-13: 9780471348894

ISBN-10: 3527303782

ISBN-13: 9783527303786

ISBN-10: 3527304428

ISBN-13: 9783527304424

This is often the 1st accomplished e-book in regards to the courting among apoptosis and autoimmune illnesses. It bargains a different updated evaluation on learn effects at the faulty execution of apoptosis and the unfinished clearance of apoptotic cells. The molecular and mobile mechanisms concerned are defined intimately. As a potential end result of apoptotic disorder, the advance of critical autoimmune illnesses (e.g., rheumatoid arthritis, systemic lupus erythematosus) is mentioned. An outlook on destiny learn themes comprises the overview of novel healing thoughts.

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Additional resources for Apoptosis and Autoimmunity: From Mechanisms to Treatments

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FADD, a novel death domain-containing protein, inter- 29 30 2 Caspase Knockouts: Matters of Life and Death 20 21 22 23 24 25 26 27 28 acts with the death domain of Fas and initiates apoptosis. Cell 1995, 81, 505–12. Boldin, M. , Varfolomeev, E. , Mett, I. , Camonis, J. H. and Wallach, D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem 1995, 270, 7795–8. Medema, J. , Kischkel, F. , Krammer, P. H. and Peter, M. E.

Rakic, P. and Flavell, R A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996, 384, 368–72. , Soengas, M. , Duncan, G. , Kaufman, S. , Lowe, S. W. and Mak, T. W. Essential contribution of caspase-3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 1998, 12, 806–19. , Braun, M. , Denis, F. and Sekaly, R. P. Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J Exp Med 1997, 186, 1503–12.

Bratton, D. L. and Henson, P. M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992, 148, 2207–16. Thornberry, N. , Bull, H. , Calaycay, J. , Chapman, K. , Howard, A. , Kostura, M. , Miller, D. , Molineaux, S. , Weidner, J. , et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 1992, 356, 768–74. Stennicke, H. R. and Salvesen, G. S. Catalytic properties of the caspases.

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Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann

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