Get Antiviral research : strategies in antiviral drug discovery PDF

By Robert L. LaFemina

ISBN-10: 1555814395

ISBN-13: 9781555814397

ISBN-10: 1555815499

ISBN-13: 9781555815493

Captures the kingdom of the technological know-how with twenty reports that study the most recent in today’s antiviral drug discovery efforts.

  • Presents the elemental ideas of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes scientific features of viral an infection with reference to remedy and toxicity.
  • Examines identified and power pursuits in any respect phases of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a huge variety of viruses, together with HIV-1, HSV, and HCV.

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150. , R. A. Barbarash, J. E. Nahlik, A. Cunningham, J. Marley, M. Heng, T. Jones, T. Rea, R. Boon, and R. Saltzman. 1995. Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann. Intern. Med. 123: 89–96. 151. Vere Hodge, R. -C. Cheng. 1993. The mode of action of penciclovir. Antivir. Chem. Chemother. 4:13–24. 152. , L. Corey, R. Cone, A.

22:55–61. 140. St. Clair, M. , W. H. Miller, R. L. Miller, C. U. Lambe, and P. A. Furman. 1984. Inhibition of cellular a DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U. Antimicrob. Agents Chemother. 25:191–194. 141. Straus, S. , K. D. Croen, M. H. Sawyer, A. G. Freifeld, J. M. Felser, J. K. Dale, H. A. Smith, C. Hallahan, and S. N. Lehrman. 1988. Acyclovir suppression of frequently recurring genital herpes. Efficacy and diminishing need during successive years of treatment.

Stamminger. CHAPTER 1 • ANTIHERPESVIRAL DNA Pol INHIBITORS 17 2005. Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina. J. Biol. Chem. 280:33357–33367. 106. Martin, J. , C. A. Dvorack, D. E. Smee, T. R. Matthews, and J. P. H. Verheyden. 1983. 9-[(1,3-dihydroxy-2-propoxy) methyl]guanine: a new potent and selective antiherpesvirus agent. J. Med. Chem. 26:759–761. 107. Martin, J. , C. E. Brown, N. Matthews-Davis, and J. E. Reardon. 1994. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis.

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Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina

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