Download e-book for iPad: Antifolate Drugs in Cancer Therapy by Robert C. Jackson (auth.), Ann L. Jackman (eds.)

By Robert C. Jackson (auth.), Ann L. Jackman (eds.)

ISBN-10: 0896034607

ISBN-13: 9780896034600

ISBN-10: 1475745214

ISBN-13: 9781475745214

ISBN-10: 1592597254

ISBN-13: 9781592597253

In Antifolate medicines in melanoma remedy, Ann Jackman and a panel of very popular researchers comprehensively assessment the present prestige of novel antifolates, a big type of anticancer medications. the prestigious participants speak about the preclinical and medical pharmacology of methotrexate, different dihydrofolate reductase inhibitors,
5-fluorouracil, and the hot new release of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. moreover, they assessment extensive the modulation of antifolate medicines, folate and antifolate delivery mechanisms, polyglutamation, resistance, and drug mixtures, in addition to pharmacogenomics, pharmacodynamics, legislation of gene expression, and mechanisms of phone loss of life.

The huge and innovative scope of Antifolate medicines in melanoma remedy presents entré to interesting new avenues for destiny learn, and constitutes a brand new general reference for all uncomplicated scientists and clinicians engaged in melanoma therapeutics.

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Mitochondrial folate accumulation and cytosolic folate accumulation require the activity of mFPGS and cFPGS, respectively. However, pteroyltriglutamates synthesized in mitochondria can move to the cytoplasm and function there, whereas the reverse does not occur, indicating a unidirectional flow of mitochondrial folate triglutamates. Cells lacking mFPGS can synthesize thymidylate and purine nuc1eotides in the cytoplasm but require glycine for growth. Cells lacking cFPGS require thymine and purines for growth (methionine is routinely added to tissue-culture media) because the mitochondrial Glu chain lengths are longer than three and cannot pass into the cytosol.

Biochernistry 1996;35: 15,772-15,783. Cook RJ, Wagner C. Enzymatic activities of rat liver cytosol lO-formyltetrahydrofolate dehydrogenase. Arch Biochern Biophys, 1995;321:336-344. Champion KM, Cook RJ, Tollaksen SL, Glometti CS. Identification of a heritable deficiency of the folate-dependent enzyme lO-formyltetrahydrofolate dehydrogenase in mice. Proc Natl Acad Sci USA 1994;91: 11 ,338-11 ,342. J olivet 1 Human 5,10-methenyltetrahydrofolate synthetase. M ethods Enzyrnol 1997 ;281:162-170. Dayan A, Bertrand R, Beauchemin M, Chahla D, Mamo A, Filion M, Skup D, Massie B, Jolivet J.

Blakley RL. Dihydrofolate reductase, In (Blakley RL, Benkovie SJ, eds) Folates and Pterins. vol. 1 Wiley, New York, 1984, pp. 191-254. 40. Hayasaka K, Nano K, Takada G, Okamura-Ikeda K, Motokawa Y. Isolation and sequenee determination of eDNA encoding human T-protein of the glyeine cleavage system. Biochern Biophys Res Cornrnun 1993;192:766-771. 41. Garrow TA, Brenner AA, Whitehead VM, Chen X-N, Dunean RG, Korenberg JR, Shane B. Cloning ofhuman eDNAs eneoding mitoehondrial and eystosolic serine hydroxymethyltransferases and ehromosomalloealization.

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Antifolate Drugs in Cancer Therapy by Robert C. Jackson (auth.), Ann L. Jackman (eds.)


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