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1989. Murine hepatic accessory cells support the proliferation of THI but not TH2 helper T lymphocyte clones. J. Exp. Med. 170:985-90 23. Kurt-Jones, E. , Belier, D. , Mizel, S. , Unanue,E. R. 1985. Identification of a membrane-associated interleukin 1 in macrophages. Proc. Natl. Acad. Sci. USA 82:1204-8 24. , Bloom, B. 1988. Interferon-7-induced transcriptional activation is mediated by protein kinase C. Proc. Natl. Acad. Sci. USA 85:5122-25 25. , Shea, C. , Thompson, R. , Boom, W. , Abbas, A.

The differentiation of CD4+ T-cell 43. Lancki, D. , Ma, D. , Havran, W. subsets in vivo. Rev. 123:189-207 54. , Fitch, F. W. 1984:.

DIFFERENTIAL REGULATIONOF T LYMPHOCYTES 31 + T lymphocytes(6). The found infrequently, if at all, amongnaive CD4 + various CD4 subsets mayarise from a commonprecursor (7, 8). Some + T lymof the factors that influence selectively the developmentof CD4 phocyte subsets following initial stimulation with antigen have been defined(6). Thefollowingdiscussion will consider primarily those mechanismsthat selectively affect TH1and TH2subsets. Theseprocesses are likely involved in the shapingof the characteristics of immune responses as they develop following immunization.

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Annual Review of Immunology Volume 11 1993 by Annual Reviews

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