By Wojciech Gorczyca
This Atlas is a vital consultant to either the prognosis and differential analysis of neoplastic hematopathologies, in line with particular parameters. it will likely be a useful reference for all training hematologists, oncologists and pathologists. Atlas of Differential analysis in Neoplastic Hematopathology, moment version discusses: uncomplicated medical information prognostic information morphologic info phenotypic info together with over six hundred colour illustrations, Atlas of Differential prognosis in Neoplastic Hematopathology, moment variation is broadly referenced and up to date. protecting neoplastic hematopathology, with an emphasis at the differential analysis, a variety of tables summarize the phenotypic profiles of the commonest hematologic tumors, for the practising hematologist, oncologist and pathologist. NEW TO the second one version: A multimethodologic method of neoplastic hematopathology New and considerably up to date sections on differential prognosis and morphology, chromosomal and genetic alterations, and localization
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Additional resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
28H) resemble lymphoblasts or myeloblasts. They are negative for MPO and NSE, and are positive for CD4 and CD56. 29 C Atypical megakaryocytes (MDS) E Reed–Sternberg cell (Hodgkin lymphoma) G B F Histiocytes (hematophagocytic syndrome) H Immature megakaryocytes (AML-M7) Osteoclast (reactive process with bone remodeling) I Cytologic features in bone marrow aspirate – megakaryocytes (see text for details). syndromes. It is recommended that at least 20 megakaryocytes are analyzed. 29A). 29C). In CML, megakaryocytes are dispersed in a background composed predominantly of myeloid precursors with leftward shift, eosinophilia and basophilia, whereas erythroid precursors often are more abundant in 5q−syndrome (and other types of MDS).
Occasional cases of precursor T-lymphoblastic lymphoma/leukemia (and less often B-ALL) have elongated cytoplasm at one pole of the cell, giving a ‘hand-mirror’ appearance to the blast cells. 28H) resemble lymphoblasts or myeloblasts. They are negative for MPO and NSE, and are positive for CD4 and CD56. 29 C Atypical megakaryocytes (MDS) E Reed–Sternberg cell (Hodgkin lymphoma) G B F Histiocytes (hematophagocytic syndrome) H Immature megakaryocytes (AML-M7) Osteoclast (reactive process with bone remodeling) I Cytologic features in bone marrow aspirate – megakaryocytes (see text for details).
CD10 expression is typical for follicular lymphoma, Burkitt lymphoma and a subset of DLBCL (B-CLL, MCL, MZL, and lymphoplasmacytic lymphoma are CD10−). MZL is negative for CD5 and CD10, but may express CD43 and CD11c. Lymphoplasmacytic lymphomas are negative for CD5 and CD10, but show admixture of plasmacytoid B-cells and plasma cells which express IgM. HCL is positive for CD11c, CD25, annexin, DBA44, and CD103. DLBCL, apart from B-cell markers, may express CD10, bcl-2, bcl-6, CD30, CD43, and MUM1.
An Atlas of Differential Diagnosis in Neoplastic Hematopathology by Wojciech Gorczyca