By Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain
Written for researchers, teachers and execs, those papers characterize an necessary reference resource at the most recent tendencies and findings within the box of proteins, amino acids and peptides. content material: Preface; Amino acid and petide bioconjugates; Self-assembling peptide fabrics; steel complexes of amino acids and peptides; version platforms for folding and teriary contacts in peptides: A viewpoint from the actual sciences; Protein nanotubes, channels and cages; Prescriptive peptide layout; focusing on alpha-helix established protein interactions - nuclear receptors as a case learn summary: Written for researchers, teachers and execs, those papers symbolize an integral reference resource at the most recent developments and findings within the box of proteins, amino acids and peptides
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Additional info for Amino Acids, Peptides and Proteins Vol. 37
M. Veronese,151 and will not be discussed in detail here. 4 Crosslinking agents The increasing arsenal of commercially available crosslinking agents allows an appropriate selection for a speciﬁc application on the basis of the chemical reactivities of the bioconjugate components as well as of other relevant properties. The characteristics to be considered are for example the chemical speciﬁcity (homo- or heterobifunctional linker), the length of the spacer arm if needs any, the cleavability of spacer, the solubility of the linker in aqueous solution, cell membrane permeability etc.
L. Meier, J. Baskin, J. A. Codelli, C. R. Bertozzi, M. A. Marahiel and M. D. Burkart, Chemistry & Biology, 2009, 16, 372. 104 H. E. Bostic, M. D. Smith, A. A. Poloukhtine, V. V. Popik and M. D. Best, Chem Commun, 2012, 48, 1431. 105 L. A. Canalle, T. Vong, P. H. H. M. Adams, F. L. van Delft, J. M. H. Raats, R. G. S. Chirivi and J. C. M. van Hest, Biomacromolecules, 2011, 12, 3692. 106 I. Kii, A. Shiraishi, T. Hiramatsu, T. Matsushita, H. Uekusa, S. Yoshida, M. Yamamoto, A. Kudo, M. Hagiwara and T.
124 The tetraazide ligation was found mutually orthogonal with strainpromoted azide–cyclooctyne cycloaddition reactions. 125 Norbornene cycloaddition. A. Hilderbrandt and co-workers. 126 This reaction is slower than the above mentioned one, but still faster than strain-promoted azide-alkyne cycloaddition. The bioorthogonality of this reaction was tested by the conjugation of norbornene and rhodamine to a monoclonal antibody. 128 Cyclobutenenorbornene ligation. Another tetrazine-base ligation (Scheme 19) was developed by Pipkorn et al.
Amino Acids, Peptides and Proteins Vol. 37 by Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain