AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo PDF

By Flossie Wong-Staal, Robert C. Gallo

ISBN-10: 0585403627

ISBN-13: 9780585403625

ISBN-10: 0824706455

ISBN-13: 9780824706456

This reference describes the most recent advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing concepts to lessen the development and transmission of AIDS. With contributions by way of universally famous experts within the box, AIDS Vaccine study discusses

  • major hindrances within the identity of a preventive vaccine
  • the position of innate immunity in administration of HIV an infection
  • the impression of hugely lively antiretroviral treatment (HAART) on AIDS learn
  • the production of a good mucosal DNA vaccine
  • the influence of the AIDS epidemic on constructing nations supplying approximately 2000 modern references to facilitate extra examine, AIDS Vaccine study is a well timed guide compatible for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate scholars in those disciplines.
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    Additional info for AIDS Vaccine Research

    Sample text

    Long, B. Doranz, J. Rucker, F. Jirik, R. Doms. 1996. A seven-transmembrane domain receptor involved in fusion and entry of Tcell-tropic human immunodeficiency virus type 1 strains. J Virol 70:6288– 6295. , M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829–833. , A. Amara, F. Bachelerie, C. L. Virelizier, F. Arenzana-Seisdedos, O. M. Heard, I. F. Legler, M. Loetscher, M. Baggiolini, B.

    Secretion of IL-4, IL-5, and IL-10) characterizes progression of HIV disease (293,296,297,303, 304). Most studies, however, suggest that cytokine dysregulation during the course of HIV infection is complex and cannot easily be classified in terms of TH1 and TH2 polarity (287,298,299,305). Effects of Cytokines on HIV Replication Soluble factors produced by activated PBMC (147), macrophages (306), and B cells (307) can dramatically upregulate HIV expression in acutely and chronically infected cells of the lymphocytic and macrophage lineage (Fig.

    Baggiolini, B. Moser. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-lineadapted HIV-1. Nature 382:833–835. R. Martin, D. R. O’Brien, J. L. VanDevanter, N. F. P. M. A. Koup. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat Med 2:412–417. , O. Labbe, C. Mollereau, G. Vassart, M. Parmentier. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene.

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    AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo


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