By Flossie Wong-Staal, Robert C. Gallo
This reference describes the most recent advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing concepts to lessen the development and transmission of AIDS. With contributions by way of universally famous experts within the box, AIDS Vaccine study discusses
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Long, B. Doranz, J. Rucker, F. Jirik, R. Doms. 1996. A seven-transmembrane domain receptor involved in fusion and entry of Tcell-tropic human immunodeﬁciency virus type 1 strains. J Virol 70:6288– 6295. , M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829–833. , A. Amara, F. Bachelerie, C. L. Virelizier, F. Arenzana-Seisdedos, O. M. Heard, I. F. Legler, M. Loetscher, M. Baggiolini, B.
Secretion of IL-4, IL-5, and IL-10) characterizes progression of HIV disease (293,296,297,303, 304). Most studies, however, suggest that cytokine dysregulation during the course of HIV infection is complex and cannot easily be classiﬁed in terms of TH1 and TH2 polarity (287,298,299,305). Effects of Cytokines on HIV Replication Soluble factors produced by activated PBMC (147), macrophages (306), and B cells (307) can dramatically upregulate HIV expression in acutely and chronically infected cells of the lymphocytic and macrophage lineage (Fig.
Baggiolini, B. Moser. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-lineadapted HIV-1. Nature 382:833–835. R. Martin, D. R. O’Brien, J. L. VanDevanter, N. F. P. M. A. Koup. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat Med 2:412–417. , O. Labbe, C. Mollereau, G. Vassart, M. Parmentier. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene.
AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo