By Carol Bernstein, Harris Bernstein
Why organisms age and why sexual replica exists are significant unsolved difficulties in biology. This publication presents an built-in clarification of getting older and intercourse in response to present wisdom of DNA harm and service. Key good points* Discusses the universality of the matter of DNA harm* Describes getting older as a result of accrued DNA harm* Considers meiosis as an variation for DNA fix* Discusses mating in eukaryotes as an version for overlaying mutation. Read more...
Read or Download Aging, Sex, and DNA Repair PDF
Similar molecular biology books
This quantity covers 2 significant subject matters: Foundations and Membrane Protein buildings. Key beneficial properties * Foundations * Bioenergetic approaches * Channels and Receptors
During this totally revised version of a longtime vintage, specialist researchers and clinicians describe in step by step aspect up-to-date recommendations for the isolation and development of significant fundamental phone kinds, comparable to kidney proximal tubule cells, hepatocytes, keratinocytes, and cardiomyocytes. The authors provide effortlessly reproducible new equipment for the differentiation of embryonic stem (ES) cells into numerous hematopoietic mobile forms, for fetal thymic organ tradition, and for the isolation and tradition of specialised telephone kinds, similar to mammary progenitor cells, skeletal muscle myofibers, mesenchymal cells, neural stem cells, hematopoietic cells, stromal telephone traces, and endothelial cells.
This MIE quantity presents laboratory recommendations that target to foretell the constitution of a protein that can have great implications starting from drug layout, to mobile pathways and their dynamics, to viral access into cells. professional researchers introduce the main complicated applied sciences and methods in protein constitution and foldingIncludes ideas on tiling assays.
Diabetes mellitus is a sickness with large well-being and fiscal burden. a greater knowing of the way basic glucose homeostasis is maintained and the pathogenesis is necessary to spot new methods for diabetes remedy. This ebook addresses a number of elements of this sector of analysis. Key gains: * Written by way of specialists within the box * Informs on very important issues regarding the rules of glucose homeostasis and the pathogenesis of diabetes mellitus, a box of severe examine curiosity
- High-Yield Cell and Molecular Biology (3rd Edition) (High-Yield Series)
- Atomic Evidence: Seeing the Molecular Basis of Life
- Biomaterials for Surgical Operation
- Principles of Clinical Pharmacology, Second Edition
Extra resources for Aging, Sex, and DNA Repair
Proc. Natl. Acad. Sei. USA 85, 9508. , and Ames, B. N. (1988). Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sei. USA 85, 6465-6467. Sagan, C. (1973). Ultraviolet selection pressure on the earliest organisms. J. Theor. Biol. 39, 195-200. Saul, R. , and Ames, Β. N. (1987). Free radicals. DNA damage, and aging. In ''Modern Biological Theories of Aging ' (H. R. Warner, R. N. Butler, R. L. Sprott and E. L. ), pp. 113-129. Raven Press, New York. , and Okada, Y.
Proc. Natl. Acad. Sei. USA 85, 6465-6467. Sagan, C. (1973). Ultraviolet selection pressure on the earliest organisms. J. Theor. Biol. 39, 195-200. Saul, R. , and Ames, Β. N. (1987). Free radicals. DNA damage, and aging. In ''Modern Biological Theories of Aging ' (H. R. Warner, R. N. Butler, R. L. Sprott and E. L. ), pp. 113-129. Raven Press, New York. , and Okada, Y. (1976). A human enzyme that liberates uracil from DNA. Biochem. Biophys. Res. Commun. 73, 293-299. Setlow, R. B. (1982). DNA repair, aging and cancer.
Apurinic-apyrimidinic sites in D N A are a frequent kind of Impairment of Replication ι 31 s p o n t a n e o u s D N A d a m a g e (Chapter 2, Section I L A ) . Strauss et al. (1982) have s h o w n that D N A replication is terminated one base before apurinic or apyrimidinic sites. T h e s e experiments were performed in vitro with D N A synthesis catalyzed by phage T4 D N A p o l y m e r a s e or E. coli p o l y m e r a s e I. D). A b b o t t s et al. (1988) reported that D N A synthesis catalyzed by E.
Aging, Sex, and DNA Repair by Carol Bernstein, Harris Bernstein