Read e-book online Aging, Sex, and DNA Repair PDF

By Carol Bernstein, Harris Bernstein

ISBN-10: 0120928604

ISBN-13: 9780120928606

ISBN-10: 0323138772

ISBN-13: 9780323138772

Why organisms age and why sexual replica exists are significant unsolved difficulties in biology. This publication presents an built-in clarification of getting older and intercourse in response to present wisdom of DNA harm and service. Key good points* Discusses the universality of the matter of DNA harm* Describes getting older as a result of accrued DNA harm* Considers meiosis as an variation for DNA fix* Discusses mating in Read more...

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Extra resources for Aging, Sex, and DNA Repair

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Proc. Natl. Acad. Sei. USA 85, 9508. , and Ames, B. N. (1988). Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sei. USA 85, 6465-6467. Sagan, C. (1973). Ultraviolet selection pressure on the earliest organisms. J. Theor. Biol. 39, 195-200. Saul, R. , and Ames, Β. N. (1987). Free radicals. DNA damage, and aging. In ''Modern Biological Theories of Aging ' (H. R. Warner, R. N. Butler, R. L. Sprott and E. L. ), pp. 113-129. Raven Press, New York. , and Okada, Y.

Proc. Natl. Acad. Sei. USA 85, 6465-6467. Sagan, C. (1973). Ultraviolet selection pressure on the earliest organisms. J. Theor. Biol. 39, 195-200. Saul, R. , and Ames, Β. N. (1987). Free radicals. DNA damage, and aging. In ''Modern Biological Theories of Aging ' (H. R. Warner, R. N. Butler, R. L. Sprott and E. L. ), pp. 113-129. Raven Press, New York. , and Okada, Y. (1976). A human enzyme that liberates uracil from DNA. Biochem. Biophys. Res. Commun. 73, 293-299. Setlow, R. B. (1982). DNA repair, aging and cancer.

Apurinic-apyrimidinic sites in D N A are a frequent kind of Impairment of Replication ι 31 s p o n t a n e o u s D N A d a m a g e (Chapter 2, Section I L A ) . Strauss et al. (1982) have s h o w n that D N A replication is terminated one base before apurinic or apyrimidinic sites. T h e s e experiments were performed in vitro with D N A synthesis catalyzed by phage T4 D N A p o l y m e r a s e or E. coli p o l y m e r a s e I. D). A b b o t t s et al. (1988) reported that D N A synthesis catalyzed by E.

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Aging, Sex, and DNA Repair by Carol Bernstein, Harris Bernstein


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