Download PDF by Roland W. Herzog, Sergei Zolotukhin: A Guide to Human Gene Therapy

By Roland W. Herzog, Sergei Zolotukhin

ISBN-10: 9814280909

ISBN-13: 9789814280907

Ever because the delivery of molecular biology, the tantalizing threat of treating sickness at its genetic roots has turn into more and more possible. Gene remedy notwithstanding nonetheless in its infancy is still one of many most well liked parts of study in drugs. Its strategy makes use of a gene move motor vehicle (''vector'') to bring healing DNA or RNA to cells of the physique in an effort to rectify the illness that's inflicting the disorder. winning treatments were said in people in recent times resembling remedies in boys with critical immune deficiencies. additionally, gene treatment thoughts are being tailored in several biomedical laboratories to acquire novel remedies for a number of ailments and to review simple organic features of affliction. Correction of sickness in animal experiences, is gradually gaining floor, highlighting the giant strength of gene remedy within the clinical career.

This publication will hide issues which are on the vanguard of biomedical study comparable to RNA interference, viral and non-viral gene move platforms, remedy of hematological ailments and issues of the primary fearful process. major specialists at the respective vector or illness will give a contribution the person chapters and clarify state-of-the-art applied sciences. It additionally provides a vast evaluation of crucial gene move vectors and such a lot widely studied aim ailments. This complete advisor is consequently a must-read for a person within the biotechnology, biomedical or clinical industries trying to additional their wisdom within the quarter of human gene treatment

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New PDF release: A Guide to Human Gene Therapy

Ever because the start of molecular biology, the tantalizing hazard of treating ailment at its genetic roots has turn into more and more possible. Gene remedy although nonetheless in its infancy continues to be one of many most popular parts of analysis in drugs. Its procedure makes use of a gene move motor vehicle (''vector'') to carry healing DNA or RNA to cells of the physique with a purpose to rectify the disorder that's inflicting the illness.

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Yew NS, et al. (2002). CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo. Mol Ther 5: 731–738. 16. Abdulhaqq SA, Weiner DB (2008). DNA vaccines: developing new strategies to enhance immune responses. Immunol Res 42: 219–232. 17. Ferreira GNM, Monteiro GA, Prazeres DMF, Cabral JMS (2000). Downstream processing of plasmid DNA for gene therapy and DNA vaccine applications. TIBTech 18: 380–388. 18. Stadler S, Lemmens R, Nyhammar Y (2004). Plasmid DNA Purification.

Takeuchi D, et al. (2008). Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model. Gene Ther 15: 561–571. 31. TaniyamaY, et al. (2002). Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther 9: 372–380. 32. Yingyongnarongkul BE, Howarth M, Elliott T, Bradley M (2004). Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.

17. Ferreira GNM, Monteiro GA, Prazeres DMF, Cabral JMS (2000). Downstream processing of plasmid DNA for gene therapy and DNA vaccine applications. TIBTech 18: 380–388. 18. Stadler S, Lemmens R, Nyhammar Y (2004). Plasmid DNA Purification. J Gene Med 6: S54–S66. 19. Nikol S, et al. (2008). Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critical limb ischemia. Mol Ther 16: 972–978. 20. Powell RJ, et al. (2008). Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia.

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A Guide to Human Gene Therapy by Roland W. Herzog, Sergei Zolotukhin


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